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An FXR agonist induces luminescence in a reporter assay using HEK293T cells expressing human FXR (EC50 18 nM) decreases the serum levels of ALT and total cholesterol as well as hepatic inflammation fat levels and fibrosis in a mouse model of NASH induced by a high-fat diet and CCl4 at 1 3 or 10 mg/kg per day
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Each vial contains nNOS (rat) to be used as a standard for WB and electrophoresis. The enzyme has been carefully purified to exclude all unrelated proteins; may not be catalytically active.{1281}
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